About Workup

In most cases, workup is not complicated.

If your reaction solvent is: ether, ethyl acetate, hexane and dichloromethane, you can simply dilute your reaction with an organic solvent and then wash with water. Ether and hexane should be diluted with a more polar organic solvent (typically ethyl acetate), so that polar products do not remain in the aqueous layer. Dichloromethane should be avoided for environmental reasons, but for small scale extractions it may be preferred, since it is denser than water and more convenient to manipulate in a separatory funnel.

If your reagents generate water-soluble waste only, they dissolve in the aqueous phase, and all you have left to do is isolate your desired product from minor organic impurities formed during the reaction.

However , sometimes workup is really problematic. Workup Tricks is a collection of strategies that are effective for different reagents, water-soluble/water-miscible solvents, tips on drying the organic layer, and troubleshooting.