CHM 402 Bio-Physical Chemistry I
Introduction to the theory and application of NMR and X-ray crystallographic techniques as used for determination of biological structures.
CHM 404 Bio-Physical Chemistry II
This course explores how fundamental interactions determine the structure, dynamics, and reactivity of proteins and nucleic acids. Examples are taken from the current literature with emphasis on thermodynamic, kinetic, theoretical, and site-directed mutagenesis studies.
CHM 411 Advanced Inorganic Chemistry I
This course covers descriptive chemistry of main group elements, bonding in inorganic systems, coordination chemistry and the properties and reactions of transition metal complexes.
CHM 414 Bio-Inorganic Chemistry
Discussion of the role of metal ions in biological systems, especially enzymes. Uptake and regulation of metals, common spectroscopic techniques used for studying metals, and mechanisms through which they react. Other topics include metal ion toxicity, metal-based drugs, and interaction of metals with nucleic acids.
CHM 415 Group Theory
Development of symmetry and group theory concepts and scope of applications to chemical problems. (2 Credits)
CHM 417 X-ray Crystallography
Students will learn the basic principles of X-ray diffraction, symmetry, and space groups. Students will also experience the single crystal diffraction experiment, which includes crystal mounting, data collection, structure solution and refinement, and the reporting of crystallographic data. (2 Credits)
CHM 421 Basic Organometallic Chemistry
Examination of the concepts, systems, reactions and applications of organometallic chemistry. Structure and bonding of complexes having carbonyl, alkyl, carbene, olefin, CnHn and related pi ligands. Oxidative addition, insertion, elimination reactions, and other fundamental reactions of organometallic compounds. (2 Credits)
CHM 422 Nuclear Magnetic Resonance Spectroscopy
An introduction to NMR spectroscopy. Collection, processing, and interpretation of homonuclear and heteronuclear 1D and multidimensional spectra will be covered. Topics to be discussed include chemical shifts, relaxation, and exchange phenomena. Examples from organic, inorganic, and biological chemistry will be used. (2 Credits)
CHM 423 Organometallic Chemistry-Survey
Mechanisms in organometallic reactions. Applications of organometallic compounds in homogeneous catalysis, polymerization, metathesis. (Fall, second half-semester) (2 Credits)
CHM 424 Inorganic Spectroscopic Techniques
Molecular and electronic structure determination of inorganic compounds and metal complexes; spectroscopic and physical methods. (2 Credits)
CHM 426 Organic Structure Determination
The modern methods and tools employed for the determination of the structure of complex organic molecules will be discussed. Among the areas discussed are basic NMR, IR, UV and mass spectroscopy. Problem solving techniques will be illustrated and problem solving skills developed by means of problem sets and class examples. (2 Credits)
CHM 433 Advanced Physical Organic Chemistry I
An understanding of the structure and reactivity of organic compounds by using molecular orbital theory will be provided. Some perspectives on the relationships between structure, mechanism and reactivity will be discussed in the context of a number of fundamental concepts and principles, such as molecular orbital theory, frontier molecular orbital theory, stereochemistry, conformational analysis, stereoelectronic effects, thermodynamics and equilibria, kinetics, linear free-energy relationships, acids and bases catalysis, nonclassical ions, and concerted pericyclic reactions.
CHM 434 Advanced Physical Organic Chemistry II
Structure and reactivity; kinetic, catalysis, medium effects, transition state theory, kinetic isotope effects, photochemistry, reactive intermediates, and mechanisms.
CHM 435 Organic Reactions
A survey of reactions of organic compounds with emphasis on those with practical synthetic utility will be provided. Mechanisms of reactions will be considered as well as their scope and limitations. Stereochemical and stereoelectronic issues will be discussed. Selected topics to be covered are conformational analysis, olefin addition reactions, oxidation and reduction methods, pericyclic reactions, chemistry of enolates and metalloenamines, organosilicon chemistry, chemistry of nitrogen- and sulfur-based functional groups, chemistry of reactive intermediates, such as carbocations and carbenes.
CHM 436 Organometallic Chemistry for Organic Synthesis
The transition metal mediated organometallic reactions most commonly employed in organic synthesis will be discussed including their substrate scope, mechanism, and stereo- and/or regiochemical course. Emphasis will be placed on the practical aspects such as catalyst and reaction condition selection, and protocols for trouble shooting catalytic cycles. (2 Credits)
CHM 437 Bioorganic Chemistry
Principles involved in design of organic molecules for recognition and catalysis in biological systems. Molecular shapes and conformations; noncovalent bonding; catalysis; drug design principles. Hands-on computer molecular modeling.
CHM 438 Advanced Synthetic Strategy
A formalism describing commonly employed strategies and tactics for the analysis of complex problems in organic synthesis will be presented. Examples of such strategies will be compared and contrasted during discussion of published complex molecule syntheses. (2 Credits)
CHM 450 Biochemistry
An introduction to biochemistry. Topics to be covered include protein and nucleic acid structure, recombinant DNA technology, bioenergetics, enzyme kinetics and mechanism, and intermediary metabolism. Lectures are supplemented with workshops.
CHM 451 Quantum Chemistry
Basic quantum chemistry, Schroedinger equation, basic postulates of quantum mechanics, angular momentum, perturbation theory, and molecular structure.
CHM 452 Quantum Chemistry II
Main topics in the advanced Quantum Chemistry course are matrix formulation of quantum mechanics, time evolution of quantum mechanical systems, density matrices, theories of molecular electronic structure, time dependent problem, and interaction of radiation with matter, including absorption, emission and multiphoton process. Weekly, there are three 50-minute lectures and homework assignments.
CHM 455 Thermodynamics and Statistical Mechanics
Synopsis: The course draws connections between the orderly and chaotic behavior of simple and complex systems, laying the foundations of statistical equilibrium and equilibrium thermodynamics. The different phases of matter (gases, liquids, solid) assumed by bulk classical interacting particles and their transitions are discussed in this approximation. Properties of non-interacting quantal systems are expressed in terms of partition functions, for gases of simple and complex particles. Non-equilibrium statistical behavior of multi-particle systems leads to diffusion and other transport phenomena.
CHM 458 Molecular Spectroscopy and Structure
The course covers the basic theory and experimental practice of spectroscopy in molecules and condensed matter. A general review of electromagnetic waves is followed by time dependent perturbation theory and a density matrix treatment of two-level systems. The basic principles are applied to NMR, ESR, electronic, vibrational and rotational spectroscopy. The course draws heavily on literature studies that exemplify the material.
CHM 459 Nonlinear Optical Spectroscopy
This course will cover a broad range of optical spectroscopic techniques and will focus on theoretical methods for their microscopic interpretation. A general correlation function methodology for analyzing nonlinear optical experiments in terms of molecular dynamics and relaxation processes will be developed. The relationships among ultrafast (time-domain) and frequency-domain techniques will be discussed. Applications will be made to fluorescence and Raman spectroscopy, three and four wave mixing, photon echo, hole burning and transient gratings in the gas phase and in condensed phases. Optical materials and nanostructures will be discussed.
CHM 460 Chemical Kinetics
A introduction to the microscopic approach to chemical reactions, including rate laws and elementary reactions, potential energy surfaces and molecular collision dynamics, photodissociation, and energy transfer.
CHM 466 Nuclear Science and Technology I
Nuclear technologies of measurement, accelerators and radiation detection, effects and applications of radiation. Fundamental particles interactions, quark model. Nuclear masses, sizes, and shapes. Overview of microscopic and macroscopic models of the nucleus. Nuclear radioactivity and decay modes. Introduction to nuclear reaction theory, classical potential scattering, semi- classical and quantal models of scattering, nuclear excitation, and mass transfer. Mathcad computer projects.
CHM 470 Computational Chemistry
In this course students will learn about a range of computational methods used to attack research problems in chemistry. Emphasis will be placed both on the theory underlying computational techniques and on their practical application. Topics will include molecular mechanics, ab initio electronic structure theory, density functional theory, molecular dynamics and Monte Carlo simulations, methods for free-energy calculations, path-integral techniques, and methods for protein structure prediction.
