Chemistry 414 » Fall » Full Semester
4 Credits
Bio-Inorganic Chemistry
Instructor(s): Patrick L. HollandPrerequisites: CHM 211/411 or equivalent.
Crosslisting: None.
Course Summary:
Discussion of the role of metal ions in biological systems, especially enzymes. Uptake and regulation of metals, common spectroscopic techniques used for studying metals, and mechanisms through which they react. Other topics include metal ion toxicity, metal-based drugs, biomaterials, and interaction of metals with nucleic acids. The course serves as an introduction to biochemistry for inorganic chemists, or as an introduction to inorganic chemistry for biochemists. A distinctive part of the course is the incorporation of extensive discussion of recent literature, and the formulation of original research proposals.
Discussion of the role of metal ions in biological systems, especially enzymes. Uptake and regulation of metals, common spectroscopic techniques used for studying metals, and mechanisms through which they react. Other topics include metal ion toxicity, metal-based drugs, biomaterials, and interaction of metals with nucleic acids. The course serves as an introduction to biochemistry for inorganic chemists, or as an introduction to inorganic chemistry for biochemists. A distinctive part of the course is the incorporation of extensive discussion of recent literature, and the formulation of original research proposals.
Course Topics:
- Overview of Biological Inorganic Chemistry
- Biogeochemical Cycles and the Occurrence of Metals
- Binding to Metals, and Folding of Proteins
- Special Cofactors in Bioinorganic Chemistry
- Transport and Storage of Metal Ions in Biology
- Biomineralization and Biominerals
- Metals in Medicine
- Hydrolysis using Metal Ions
- Electron Transfer, Respiration, and Photosynthesis
- Oxygen Metabolism
- Hydrogen, Nitrogen, Carbon, and Sulfur Metabolism
- Radicals in Metalloenzymes
- Metal Ion Receptors and Signaling
Required Text:
Biological Inorganic Chemistry (Bertini, Gray, Stiefel, Valentine)
Biological Inorganic Chemistry (Bertini, Gray, Stiefel, Valentine)